Bollerslev J, et al. European Society of Endocrinology Clinical Guideline: Treatment of chronic hypoparathyroidism in adults. Eur J Endocrinol. 2015 Aug;173(2):G1-20.
Brandi ML, et al. Management of Hypoparathyroidism: Summary Statement and Guidelines. The Journal of Clinical Endocrinology & Metabolism. 2016 Jun 1;101(6):2273–83.
Chen K, et al. Clinical burden and healthcare resource utilization among patients with chronic hypoparathyroidism, overall and by adequately vs not adequately controlled disease: a multi-country chart review. Journal of Medical Economics. 2019 Jun 17;22(11):1141–52.
Mannstadt M, et al. Hypoparathyroidism. Nat Rev Dis Primers. 2017 Aug 31;3:17055.
Clarke BL, et al. Epidemiology and Diagnosis of Hypoparathyroidism. J Clin Endocrinol Metab. 2016 Jun 1;101(6):2284–2299.
Khan AA, et al. Standards of care for hypoparathyroidism in adults: a Canadian and International Consensus. Eur J Endocrinol. 2019 Mar 01;180(3):1-22.
Karpf D, et al. Prevalence of hypoparathyroidism in the EU: A systematic review and meta-analysis. Endocrine Abstracts. 2020;70:AEP140.
Shoback DM, et al. J Clin Endocrinol Metab. 2016;101(6):2300–12.
Brod M, et al. Living with hypoparathyroidism: development of the Hypoparathyroidism Patient Experience Scale-Impact (HPES-Impact). Qual Life Res. 2021 Jan;30(1):277-291. doi: 10.1007/s11136-020-02607-1. Epub 2020 Aug 24. PMID: 32833143; PMCID: PMC7847873.
Kontogeorgos G, et al. Low health-related quality of life in hypoparathyroidism and need for PTH analog. Endocrine Connections. 2022 Jan 10;11(1).
Impact of hypoparathyroidism on quality of life, physical functioning and psychological wellbeing
The burden of hypoparathyroidism (also known as hypopara) negatively impacts health-related quality of life, physical functioning, and psychological well-being, regardless of serum calcium levels. 2, 17, 18
Brain
Central nervous system
Tab 1 content.
Tab 2 content.
Impact on quality of life
In a survey of 42 people living with hypopara, the respondents reported the following impacts on their daily life, mental health, activity and social life & relationships. 17
Daily Life 17
79%
were not able to do as many things around the home
43%
said that hypopara interferes with their ability to work
67%
were unable to do as much as they used to/want to
Mental Health 17
81%
felt anxious or had anxiety
64%
felt frustrated
62%
felt depressed or sad
Activity 17
76%
were not able to exercise in the same way
52%
are less active than they used to be/want to be
50%
were not as mobile (including ability to walk)
Social Life & Relationships 17
79%
were less able to engage in social activities
57%
were limited in the types of social activities they could do
43%
said hypopara affected their relationships with family