1. Bollerslev J, et al. European Society of Endocrinology Clinical Guideline: Treatment of chronic hypoparathyroidism in adults. Eur J Endocrinol. 2015 Aug;173(2):G1-20.
  2. Brandi ML, et al. Management of Hypoparathyroidism: Summary Statement and Guidelines. The Journal of Clinical Endocrinology & Metabolism. 2016 Jun 1;101(6):2273–83.
  3. Chen K, et al. Clinical burden and healthcare resource utilization among patients with chronic hypoparathyroidism, overall and by adequately vs not adequately controlled disease: a multi-country chart review. Journal of Medical Economics. 2019 Jun 17;22(11):1141–52.
  4. Mannstadt M, et al. Hypoparathyroidism. Nat Rev Dis Primers. 2017 Aug 31;3:17055.
  5. Clarke BL, et al. Epidemiology and Diagnosis of Hypoparathyroidism. J Clin Endocrinol Metab. 2016 Jun 1;101(6):2284–2299.
  6. Khan AA, et al. Standards of care for hypoparathyroidism in adults: a Canadian and International Consensus. Eur J Endocrinol. 2019 Mar 01;180(3):1-22.
  7. Karpf D, et al. Prevalence of hypoparathyroidism in the EU: A systematic review and meta-analysis. Endocrine Abstracts. 2020;70:AEP140.
  8. Shoback DM, et al. J Clin Endocrinol Metab. 2016;101(6):2300–12.
  9. National Cancer Institute. Bone Density. Available from: https://www.cancer.gov/publications/dictionaries/cancer-terms/def/bone-density. [accessed October 2025].
  10. Medline Plus. Calcification. Available from: https://medlineplus.gov/ency/article/002321.htm [accessed October 2025].
  11. National Cancer Institute. Cognitive impairment. Available from: https://www.cancer.gov/publications/dictionaries/cancer-terms/def/cognitive-impairment. [accessed October 2025].
  12. Institute of Medicine. Dietary Reference Intakes for Calcium and Vitamin D. Washington, DC: The National Academies Press; 2011.
  13. Qadeer HA, Bashire K. Physiology, Phosphate. StatPearls. 2020. Available from: https://www.ncbi.nlm.nih.gov/books/NBK560925/. [accessed October 2025].
  14. Goyal A, et al. Hypocalcemia. StatPearls. 2020. Available from: https://www.ncbi.nlm.nih.gov/books/NBK430912/. [accessed October 2025].
  15. Goyal R, Jialal I. Hyperphosphatemia. StatPearls. 2023. Available from: https://www.ncbi.nlm.nih.gov/books/NBK551586/. [accessed October 2025].
  16. National Cancer Institute. Renal Failure. Available from: https://www.cancer.gov/publications/dictionaries/cancer-terms/def/renal-failure. [accessed October 2025].
  17. Brod M, et al. Living with hypoparathyroidism: development of the Hypoparathyroidism Patient Experience Scale-Impact (HPES-Impact). Qual Life Res. 2021 Jan;30(1):277-291. doi: 10.1007/s11136-020-02607-1. Epub 2020 Aug 24. PMID: 32833143; PMCID: PMC7847873.
  18. Kontogeorgos G, et al. Low health-related quality of life in hypoparathyroidism and need for PTH analog. Endocrine Connections. 2022 Jan 10;11(1).

Prevalence, symptoms, and impact on quality of life.

Fact sheet with symptom diagram Download

August 2025
GL-COMMPTH-2500042

Prevalence and impact on quality of life.

Fact sheet without symptom diagram Download

August 2025
GL-COMMPTH-2500043

If you have been diagnosed with hypoparathyroidism, you can use this diary to keep a daily record to help you track your symptoms.

Patient diary tool Download

November 2025
GL-COMMPTH-2500052

Support materials

Man with blue shirt sitting outside

Improving understanding of hypoparathyroidism

Seeds of Change aims to support and empower people with hypoparathyroidism (also known as hypopara), so they are ready to advocate for improved care and quality of life.

The materials below are intended to help improve understanding and support patients, their loved ones, caregivers, and healthcare professionals in having meaningful discussions around hypopara care.

Tab 1 content.

Tab 2 content.

Download support materials

Click below to download hypoparathyroidism materials

Fact sheet with symptom diagram

Hypoparathyroidism

Prevalence, symptoms, and impact on quality of life.

August 2025
GL-COMMPTH-2500042

Preview Download
Fact sheet without symptom diagram

Hypoparathyroidism

Prevalence and impact on quality of life.

August 2025
GL-COMMPTH-2500043

Preview Download
Patient diary tool

Hypoparathyroidism

If you have been diagnosed with hypoparathyroidism, you can use this diary to keep a daily record to help you track your symptoms.

November 2025
GL-COMMPTH-2500052

Preview Download